I have my web site running on Zope with mysql. Since zope is going to sleep every now and then, I am currently moving on to PHP.
For the parts of my web site which are database intensive(which causes zope to crash) I do a form post(from a Zope Page) to a PHP file running on another apache server on a different port. After processing the data, I redirect to the "thank you" page which is on zope again.
u can see it happen here.
http://www.zdnetindia.com/chipmag/contest_form