1) Explode the whole thing into an array via some suitable marker (don't use the <br> as the marker). So let's say the marker is the word 'break'
$array = explode("break", $string);
2) After that, count how many keys (sections) the array has.
3) Determine the last key and assign it to a string, i.e, $string2
4) Strip any <br> tags from it via the eregi_replace function, i.e.
eregi_replace("<br>", " ", "$string2");
5) Replace the array's last key with the new value of $string2 via...
$array["last key"] = "$string2";
That statement says: 'find any <br>'s replace them with a space in the $string string.'
Alternatively if you know the <br> tag is the last part of the string you can just strip it via a substring i.e.
$newstring = substr($string, 0, -4);
//since the <br> is 4 characters long
Hope this helps.