Hi,
At first you should save your excel sheet as a csv-file!
That means that all values will be seperates in a file with commas (csv = comma seperated values).
Now you can import this csv-file to your mysql-database.
The easiest way is to use a tool like phpmyadmin or something like that, but if you can also make a query like this:
mysql> LOAD DATA INFILE "/tmp/file_name" INTO TABLE test IGNORE 1 LINES;
For a better explanation see:
http://www.mysql.com/doc/en/LOAD_DATA.html
Hope this helps