It's really quite easy...
in MySQL:
load data infile '/path/to/file.txt' into table TABLENAME
file.txt should be a tabbed text file. That's really the easiest way.
If your table has more fields than the txt file, you can also do this:
load data infile '/path/to/file.txt' into table TABLENAME (field1, field2,field4,field7)
Check out the MySQL site [ http://www.mysql.com ] you will find a lot of helpful information.
-- Jason