There are a couple of ways you can do it...
You can have all of your information for the user in one table, or you can have a user table and a profile table with the user's unique ID referenced in the profile table.
OR... if you really want to split it up for fastest searching, have a user table with UID and Profile table with a PID, then a cross reference table that just has the UID and PID.
That can create some headaches pulling information out if you're kinda new to SQL.