Two approaches depending on how you're playing with the data...
First one is via SQL:
SELECT SUM(Downloads) AS dltotal FROM mytable GROUP BY Downloads
You can use SUM() to add up all the values. Trick is you will only get 1 row which contains the answer.
The 2nd trick is if you wish to pull in the name of the download and the number of downloads, you could tell PHP to keep track of the total number of downloads. In your PHP loop you have to retrieve all the records, you could put in the loop something like: $totaldownload += [variable with this record's number of downloads]
Then $totaldownload gets updated for every record you loop through.