Sure you can.
First, start by making a base layout in one page. Then separate it into a header.php and a footer.php
Then for your pages, just add the content but include the headers and footers.
Example: Create an aboutme.php page.
<? include('header.php'); ?>
my about me content goes here. my about me content goes here. my about me content goes here. my about me content goes here. my about me content goes here. my about me content goes here.
<?php include('footer.php'); ?>
Include files really help separate the content from the layout format. 🙂