Not that I personally know of, but it can be done in PHP.
My advices and guidelines to start your coding.
1 - Use phpmailer to send your probe messages to the members of your list. Foreach email sent, add a customer header, using the method AddCustomHeader(), lets say something like : AddCustomHeader("ProbeID: $some_unik_id_liked_to_the_user");
http://phpmailer.sourceforge.net/docs/PHPMailer/PHPMailer.html#AddCustomHeader
2- Now loop through the bounce messages you get in the email box you used to send your probe messages (if you are lucky enough to have you own server), grab the ProbeID line from the header of each messages, and with the ID, delete or change the status of the member to inactive.
Hope this helps a little.