http://www.zend.com/zend/week/week135.php
Their quote "If 40%+ of your total script size are comments you may see something like a 2-4% performance boost if you remove those comments for files >40kb."
Now it doesn't say whether that's a script just doing calculations or if it's doing a reasonable amount of outputting. Combine the script execution with the relative slowness of the net and it's possible even more insignificant.