Make an array:
$dayArray = array('M', 'T', 'W', 'Th', 'F', 'Sa', 'Su');
if(($day = array_search($_GET['day'], $dayArray)) === FALSE) die('Improper day selected.');
// $day is now the appropriate number.
NOTE: In the above example, Monday = 0, Tuesday = 1, etc. If you would rather start Monday at one, use the following array instead:
$dayArray = array('', 'M', 'T', 'W', 'Th', 'F', 'Sa', 'Su');
EDIT: Be aware of what version of PHP you're using, too:
Note: Prior to PHP 4.2.0, array_search() returns NULL on failure instead of FALSE.
(Quote taken from the manual entry for [man]array_search[/man])
EDIT2: Also forgot to mention, this is case-sensitive. Be aware of that when you're putting the values into the HTML form.