Let's assume, that you've got $email_to from a form. Checking if it's all righ can look like this:
if (preg_match("/(domain.com$)|(another.net$)|(some.edu$)/",$email_to)
{
//send email
}
else echo "This domain is not allowed.";
The construction above would match aaa@domain.com as well as bbb@more.some.edu.
but not domain.com@foe.server.uk
You can be as specific as you like (even the whole email address).