How the PHP optimisers work, is that they pre-compile your scripts as byte-code (into memory or temporary files typically). This saves a lot of startup time parsing the PHP files.
Normally, a well written application contains a lot of reused code, i.e. code shared between several scripts - sometimes a lot of code is included in a given script, then not used (because it's only there for consistency).
The accelerator saves most of the startup time parsing your script and inside include(), require() statements etc.
It typically does not optimise the runtime of your code much (if at all).
However, this startup time can be a large proportion of the time taken, particularly for a simple page. Or something like Smarty which compiles its templates into .php files (which is very cunning, seeing as they can then be precompiled by the accelerator).
Weedpacket: yes, Zend's optimiser is semi-official, but it isn't shipped with, or considered part of PHP, rather it's something which Zend ship (or sell?) independently under its own licence.
Mark