disabling the button after a click stops the user from getting impatient and clicking it again.
this is good usually to stop multiple INSERT querys to be executed.. like a system that sends personal messages might disable their button after pressing it so that the message isnt sent twice..
it probably wont make a difference with your script however because regardless of if the image is uploaded all the way when the button is pressed again, it will just write over the original image and it shouldnt cause any problems.