Heres one way
$var1= 4;
$var2= 5;
$sql = sprintf("UPDATE some_table SET field = %d + %d WHERE id = 1",$var1,$var2);
mysql_query($sql);
In case i missunderstood
$query="SELECT sum(some_field) FROM table WHERE id=1";
$result=mysql_query($query);
$sum=mysql_fetch_row($result);
$query=sprintf("UPDATE table SET field = %d WHERE id = 1",$sum[0]);
mysql_query($query);