If the two tables are independent of each other and you simply want to list each serial/agen pair from both tables where agen has some value, then I think you are stuck with two queries (and asking yourself why they are separate tables).
If there is some relationship between the rows in the two tables that have the same value for the agen column, then you could do a join, but it's not clear to me whether that is applicable for this.
SELECT w1.serial, w1.agen, w2.serial, w2.agen
FROM week1 w1 INNER JOIN week2 w2 ON w1.agen = w2.agen
WHERE w1.agen = 269