Let me ask you this,
these hotels, do they have their own reservation system and are simply entering data into your website on a interval basis, like daily or every few hours, or are you looking to provide a hotel or hotels with an online interface in which to actually do the booking and reservation?
Basically, how consistent will room availabity be between hotels updating on and off on your website, and how crucial to your operation is for the data to be 100% real time and accurate?
If you are looking for an all inclusive portal for reservation management and booking, then this project is probably beyond regular scope.
But if your looking for a simple "this is what we offer, contact us for more info" sort of portal, then hosting your website online and simply giving hotels username/password combos to an admin section of the website will take care of your database sharing problems