It really doesn't matter 😉 You can leave them in the post array, you can put them in your own new array, you could create variables for each of them. Heck, you could really create an XML, then read it in via a simplexml object 😛
The way to secure your queries is to use [man]mysql_real_escape_string/man to properly escape characters, and if you really want to be cautious, you could use [man]sprintf[/man] to mke the inputs even more defined as to what type of data it is.
For example:
$query = sprintf("INSERT INTO `tablename` (`column`, `column`, `column`, `column`) VALUES ('%d', '%s', '%d', '%s')",
mysql_real_escape_string($_POST['something']),
mysql_real_escape_string($_POST['something']),
mysql_real_escape_string($_POST['something']),
mysql_real_escape_string($_POST['something']));