Store them as either DATETIME or TIMESTAMP types in the DB, depending on whether or not you need the added ability of TIMESTAMP types to automatically set themselves on insert or update queries. If the value in your PHP script is a PHP timestamp integer, you can convert it to the necessary date string via the [man]date[/man] function:
$dateString = date('Y-m-d H:i:s', $dateTimeVariable);
$sql = "INSERT INTO table_name (`date_time_col`) VALUES('$dateString')";