Sure
Using md5_file()
With a 1MB file:
Hash = df1555ec0c2d7fcad3a03770f9aa238a; time = 0.005006With a 2MB file:
Hash = 4387904830a4245a8ab767e5937d722c; time = 0.010393
With a 10MB file:
Hash = b89f948e98f3a113dc13fdbd3bdb17ef; time = 0.241907