So you have your email list and you want to avoid mailing folks who are on an exclusion list, right?
Unless your lists are quite small (1,000 names or less) then you probably should use a database approach. You put your active email list in one table:
email_list
-- id
-- email
and you put the exclusion list in another table
email_exclude
-- id
-- email
and then you can get all the emails that are NOT in the exclusion list by doing something like this:
SELECT el.email FROM email_list el LEFT JOIN email_exclude ee ON ee.email=el.email WHERE ee.email IS NULL
I haven't tested that but it should be close to what you need.