EDIT: Thanks weedpacket!
Hmmm. http://mydomain.com/majors is a valid url. I believe your suggestion would send 404 whenever someone tries to access it.
To clarify. This url is valid
http://mydomain.com/majors
This may or may not be valid, depending on whether my map program is able to locate CIP in my database table:
http://mydomain.com/majors/somefile.php?cip=40.0299
I cannot know if the code is valid or not until the map program has looked it up.