If it's MySQL, there's a script called "mysqltuner.pl" (written in PERL) for any PERL-enabled server environment; running it may help you do some "tuning" of the server.
Enabling the "slow queries log" is also worth it, probably.
If you have queries that you don't know what do, or, once you find queries in the slow log, run then through EXPLAIN.
MySQL also has some good tutorials ... I'll see if I can find a link to a webinar I attended.