Actually, I doubt that there's anyone here with much experience using ODBC drivers for Excel as a database, for the same reason few have any experience using the text-file ODBC driver (yes, there is such a thing)--neither underlying format has what it takes to be used as a database for more than a single user. Access to Excel files is completely document-centric; meaning especially that when the file is updated, the whole file has to get rewritten before the changes are visible to anyone else.
Those ODBC drivers are there primarily to be used for importing data from those formats, or exporting to those formats. But note again, those things too are also very much single-user/document-centered.