You might clean up the data already in the table by running a process that finds these records. (Anywhere you see a '+' in the following example, substitute a space.)
SELECT * FROM table WHERE field LIKE '%,++%'
Then iterate a loop on the resultset for each row. Scrub out multiple spaces (regular expressions are your friend!) and perform an update:
UPDATE table SET field = $scrubbed_field WHERE id = $id
This process shouldn't take up a whole lot of time, and will save you lots of headaches. Just be sure to scrub all new data before inserting it into your table.