Depends on whether you want this to mean a trip back to the server or not.
If there is a lot of data (manufacturers and models) then a server round trip is best. Simply force a refresh when the combo is changed ensuring the server gets the new value and can select data for the model combo accordingly. The refresh needs to be forced through javascript.
If you mave minimal data that is reasonably static you could do this in javascript and not involve the server. Not the best option though with lots of data.
Cheers,
Cris