You may be running out of file handles. If that happens your system will thrash and slow to a crawl.
What OS are you running? linux? If so, you can check the number of file handles in use by doing
'cat /proc/sys/fs/file-nr'
The first number is the max used in a long while, the second is the current number used, and the third number is the maximum your system can handle.
You can change it, as root, if you do a
'echo xxxx >/proc/sys/fs/file-max'
where xxxx is the new max you want. 20000 or so should be enough.
while you're there, look at /proc/sys/fs/inode-nr and inode-max