How about this:
$column = "description";
$change_from = "/";
$change_to "#";
$query = "UPDATE table SET $column = REPLACE($column,'$change_from','$change_to')";
$result = mysql_query($query);
I think that's what you mean...
$column, $change_from, and $change_to would be constants or set dynamically, of course.
---John Holmes...